Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for pepubertal gynecomastia in boys with Peutz-Jeghers Syndrome
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(2013). Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for pepubertal gynecomastia in boys with Peutz-Jeghers Syndrome. Take down policy If you believe this document infringes copyright, raise a complaint by contacting [email protected]. The document will be immediately withdrawn from public access while the complaint is being investigated.
منابع مشابه
Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz-Jeghers syndrome.
CONTEXT Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. PJS males often have estrogen excess manifesting as gynecomastia and advanced bone age. We and others have previously described an increase in testicular aromatase expression in PJS patients. However, the underlying mechanism has not yet been expl...
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